MAPT and Alzheimer disease: have established an AD‐like rat model by injection of Hcy (400 μg/kg/day) for 14 days via the vena caudalis (Zhang et al., 2008), and Hcy‐treated rats showed typical AD‐like spatial learning and memory deficits, synaptic impairment and loss, tau hyperphosphorylation, and Aβ overload, which indicated that Hcy‐treated Sprague–Dawley rat is a suitable model for AD studies (Mahaman et al., 2018; Zeng et al., 2019; Zhang et al., 2019).