Although the differences by APOE ε4 status were nonsignificant, we observed slightly stronger positive effects of PDI and hPDI, but stronger negative effects of uPDI on cognitive impairment among APOE ε4 carriers than non‐ε4 carriers (PDI: OR = 0.44 [95% CI: 0.30, 0.66] vs. OR = 0.41 [95% CI: 0.34, 0.51]; hPDI: OR = 0.68 [95% CI: 0.47, 1.00] vs. OR = 0.60 [95% CI: 0.50, 0.73]; uPDI: OR = 2.11 [95% CI: 1.45, 3.05] vs. OR = 2.06 [95% CI: 1.71, 2.47]). This evidence concerns the gene APOE and Cognitive impairment.