IGF2BP1, IGF2BP3, IGF2BP2, DNMT3B, DNMT3A, DNMT1, NSUN7, NSUN5, ALYREF, METTL3, TRMT6, and TRMT61A were overexpressed in HCC tissues relative to normal tissues. The gene discussed is DNMT3A; the disease is hepatocellular carcinoma.