A full understanding of lipid networks in relation to mast cells, allergy, and other mast cell-dependent biological events should be further elucidated using advanced techniques such as spatiotemporal lipid imaging, untargeted lipidomics, and novel pharmacological tools to manipulate the activity or expression of particular PLA2 subtypes that would have a potential to sequester allergic or other diseases. Here, PLA2G6 is linked to allergic disease.