Furthermore, mast cell-specific Pla2g3-deficient mice, as well as mast cell-deficient KitW-sh mice reconstituted with mast cells prepared from global Pla2g3–/– mice, display a significant reduction of irritant contact dermatitis (ICD) and an aggravation of Th1-dependent CHS (21). This evidence concerns the gene PLA2G3 and impulse control disorder.