While sPLA2-IIA promotes sterile inflammation by mobilizing pro-inflammatory lipid mediators or DAMPs (danger-associated molecular patterns) from EVs as an “inflammatory sPLA2” (115), it also efficiently degrades bacterial membranes (Gram-positive in particular), thereby playing a protective role against bacterial infection as a “bactericidal sPLA2” (124). This evidence concerns the gene PLA2G10 and bacterial infectious disease.