This sPLA2-III-L-PGDS-DP1 paracrine circuit highlights a new aspect of PGD2-DP1 signaling in the regulation of mast cell maturation and thereby allergy and provides evidence for the long-standing proposal that sPLA2 acts as a paracrine coordinator of eicosanoid production in tissue microenvironments (20). Here, PLA2G2A is linked to Allergy.