GO and KEGG enrichment analyses exhibited that most genes in these modules were enriched in cell proliferation and tumorigenesis-related pathways including DNA replication, P53 signaling pathway, cell cycle, and cell division pathways, indicating that the inhibition of cell proliferation processes might be a potential mechanism for bevacizumab to suppress the progression and migration of CRC. This evidence concerns the gene TP53 and colorectal carcinoma.