TLR4 and myeloid sarcoma: Branched N-glycans have been reported to suppress B cell triggered proinflammatory Th1/Th17 differentiation by promoting Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) endocytosis and downstream APC activity in B cells, thereby reducing inflammatory demyelination in a murine model of MS.