IL1B and COVID-19: In patients with moderate disease, the core COVID-19 inflammatory cytokine signature with IL-1a, IL-1b, IL-17A, and IFN-α observed in the first 10 days from symptom onset declined steadily (142) and the same happens with the innate cytokine IL-12, a key inducer of Th1 immune response, as well as IFN-γ (142).