CD4 and COVID-19: Evidence suggesting that the above described process is indeed what occurs following SARS-CoV-2 infection have been provided by Mudd PA et al. (155) given that a high-magnitude, SARS-CoV-2-specific CD4+ T cell response in the draining lymph nodes is present during the development of high-titer neutralizing antibody responses in the setting of COVID-19 mRNA vaccination.