MPO and asthma: In terms of the systemic manifestations, renal involvement occurred more frequently in the MPO-ANCA–positive group (80.0% vs. 35.5%, p < 0.0001), whereas cardiac lesions (38.7% vs. 12.0%, p = 0.01) and asthma (76.3% vs. 56.0%, p = 0.04) presented more commonly in the ANCA-negative group.