The pathogenesis of RA involves many immune cells and cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-18 (IL-18), and tumor necrosis factor (TNF) as the main pro-inflammatory cytokines, which induce inflammatory response and osteoarthritis injury (6). This evidence concerns the gene IL18 and rheumatoid arthritis.