JAG1 and cancer: Served as one of the 5 cell surface ligands that functioned primarily in the highly conserved Notch signal pathway, JAG1 was activated by NPMSC cells and acted on other cell populations through JAG1/Notch signaling pathway, which also had essential roles in cancer stem cell differentiation and metastasis, and it was also related with diverse non-tumor diseases including liver, heart, skeletal etc., most were functioned by JAG1/Notch signaling pathway (49, 50).