Researchers induced iPSC differentiation in pluripotent stem cells to obtain CAR-expressing iPSC-derived macrophages (CAR-iMac) and found that CAR-iMac cells showed antigen-dependent phagocytosis and cytotoxicity toward tumor cells, as well as antigen-dependent polarization effect on M1 macrophages, when co-cultured with lymphoma cells expressing CD19 antigen or ovarian cancer cells expressing mesothelin antigen (103). Here, CD19 is linked to neoplasm.