(77) found that intratumoral injection of tumor-selective oncolytic bovine poxvirus encoding IL-7 and IL-12 into immunocompetent tumor-bearing mice altered the TME immune status, activated inflammatory immune status in previously poorly immunogenic tumors, had anti-tumor activity in both tumors that are directly injected with this oncolytic bovine poxvirus and those that are not injected distantly with this oncolytic bovine poxvirus, and even led to a complete tumor response. The gene discussed is IL7; the disease is neoplasm.