Plinabulin, a novel selective immunoregulatory microtubule binder (SIMBA)Toll-like receptor 9 (TLR9) agonists: SD-101, CMP-001Oncolytic viruses (OVs) and modified OVs: BiTE-integrated OVs, in situ OVs (showing adenovirus-mediated herpes simplex virus thymidine kinase expression)Therapeutic tumor vaccines: Sipuleucel-T, OSE-2101, PVX-410 vaccine, folate receptor α vaccine, and neoantigen vaccine. This evidence concerns the gene TLR9 and neoplasm.