A clinical overlap between COVID-19 and anti-MDA5 syndrome has been described, especially in the terms of rapidly progressive interstitial lung disease (ILD), fever, myalgia, and skin rashes; also, imaging findings show significant similarities, i.e. bilateral ground-glass pneumonitis and peri-bronchovascular consolidations (13, 14). This evidence concerns the gene IFIH1 and interstitial lung disease.