While PFD did not affect the total number of NLRP3 positive cells in pulmonary arterioles nor caspase‐1 cleavage, it did inhibit IL‐1β and IL‐18 cleavage in lung tissue, indicating that PFD inhibited the production of the main NLRP3 inflammasome products that regulate its downstream effects. The gene discussed is IL18; the disease is polyostotic fibrous dysplasia.