Cleaved IL‐1β and IL‐18, products of NLRP3 inflammasome activation, were also significantly increased by twofold and threefold, respectively, in lung homogenate of PAH animals compared to control, which was reversed by PFD (35% and 65%, respectively) (Figure 4c–f). The gene discussed is IL1B; the disease is pulmonary arterial hypertension.