NLRP3 and pulmonary arterial hypertension: In this study, we investigated whether the NLRP3 inflammasome is activated in a rat model of flow‐associated neointimal PAH, induced by monocrotaline (MCT), and aortocaval shunt and whether early PFD treatment affects NLRP3 inflammasome activation, pulmonary hemodynamics, and vascular remodeling.