Rutin boosts the levels of estrogen receptor alpha and beta (ERα and ERβ), which modulate the growth, survival and metabolism of cells by regulating downstream targets and activating the BDNF-TrkB and NGF-TrkA signaling pathways, to mitigate cerebral ischemia injury (Liu et al., 2018). The gene discussed is ESR1; the disease is Cerebral ischemia.