Artemisinin, tetrandrine, cannabidiol, oxymatrine, and geniposide directly reduce the expression of proinflammatory cytokines such as IL-6, IL-1β, IL-17A, and TNF-α (Liu et al., 2015b; Watt and Karl, 2017; Qiang et al., 2018; Chen Y. et al., 2019; Ren et al., 2021) to control AD. The gene discussed is IL6; the disease is Alzheimer disease.