In the treatment of AD, tanshinone IIA, ginsenoside Rd, cannabidiol, oxymatrine, cholic acid, vitamin A, puerarin, icariin, geniposide and curcumin prevent and ameliorate AD by diminishing Aβ deposition and tau protein phosphorylation (Liu et al., 2015a; Karch and Goate, 2015; Zeng J. et al., 2017; Tang and Taghibiglou, 2017; Watt and Karl, 2017; Yan et al., 2017; Yao et al., 2017; Chen Z. et al., 2019; Jin et al., 2019; Majid et al., 2019; He et al., 2020; Fu et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.