Salvianolic acid B increases TGF-β (acting as an anti-inflammatory factor) to palliate depressive-like behaviors in depressive patients (Zhang et al., 2016), whereas icariin reduces TGF-β (acting as a proinflammatory factor) to treat cerebral ischemia (Jin et al., 2019). This evidence concerns the gene TGFB1 and Cerebral ischemia.