SIRT2 and cyclic hematopoiesis: Some studies have shown that Met can activate AMPK and thereby resist CH by reducing O-GlcNAcylation (Gélinas et al., 2018a; Gélinas et al., 2018b), or AMPK activates SIRT2 to decrease aging-related and Ang II–induced CH (Tang et al., 2017).