In some heart disease models, such as congestive heart failure and valvular heart disease, VEGF-A expression showed a positive correlation with the expression of HIF-1α (Lee et al., 2019) and studies have proved that VEGF-A is one of the downstream targets of HIF-1α indeed (MacDonald et al., 2013; Wen et al., 2019). This evidence concerns the gene HIF1A and heart valve disorder.