STAT3 and colorectal carcinoma: Based on a 1H NMR metabolomics analysis of serum from dimethylhydrazine (DMH)-induced CRC rat model, the disordered metabolic fluxes in CRC condition, including glycolysis, TCA cycle, gluconeogenesis and phosphatidylinositol metabolisms, were reversed after M1 treatment through the oncogenic signalling inhibition of IL-6/JAK2/STAT3 (Mishra et al., 2018).