In the meanwhile, 12OH-BAs such as CA and DCA were decreased in TB and TB + PCP groups, which were reported to promote lipogenic gene expression stearoyl-CoA desaturase 1 (SCD1), including, fatty acid synthase (FAS) and sterol regulatory element-binding protein 1 (SREBP-1) (Jia et al., 2021). The gene discussed is FAS; the disease is tuberculosis.