TEF was controlled by the circadian rhythm and affected the expression of other rhythmic and functional genes [48], suggesting the modulation of TFE-mediated downstream effectors by CRY2 and DBP. What is more, due to correlation of CRY2 and immune cells, immune infiltration was mainly contributed by CRY2, thus influencing the occurrence and progression of glioma. This evidence concerns the gene CRY2 and glioma.