Four clinical phenotypes of NLRC4 inflammasome‐related diseases, because of gain‐of‐function NLRC4 mutations, have been reported; autoinflammation and infantile enterocolitis (AIFEC), NLRC4 macrophage activation syndrome (NLRC4‐MAS), familial cold autoinflammatory syndrome (FCAS) and chronic infantile neurological cutaneous and articular (CINCA), also known as neonatal‐onset multisystem inflammatory disease (NOMID).116. Here, NLRC4 is linked to familial cold autoinflammatory syndrome.