However, in these same studies, IL‐1β expression was increased in the colon of Nlrp6−/− mice79 and both IL‐1β levels and caspase‐1 activity were comparable between Nlrp6−/− and WT mice following infection with various bacteria,72 making it unclear whether NLRP6 inflammasome assembly occurs during systemic bacterial infection. Here, NLRP6 is linked to infection.