Monocytes from CAPS patients and DCs from mice harbouring CAPS‐related mutations also produce elevated IL‐18, and mouse models of CAPS have shown that IL‐1β and IL‐18 drive the pathology at different disease stages, with IL‐18 contributing to early inflammation and IL‐1β to later systemic inflammation.200. Here, IL1B is linked to cryopyrin-associated periodic syndrome.