Cryopyrin‐associated periodic syndromes also known as NLRP3‐associated autoinflammatory diseases (NLRP3‐AIDs) comprise a series of rare monogenic autoinflammatory conditions which range in severity from the mildest FCAS, to the moderate Muckle–Wells syndrome (MWS), and more severe CINCA/NOMID.191. This evidence concerns the gene NLRP3 and CINCA syndrome.