NLRP3 and COVID-19: Indeed, coronaviruses have been shown to activate the NLRP3 inflammasome, via either indirect interaction with NLRP3 (SARS‐CoV E viroporin protein, viroporin 3a) or direct activation with NLRP3 (SARS‐CoV‐2 N protein), resulting in hyperinflammation and increased COVID‐19 severity.64, 65, 66