An additional role of AIM2 has emerged, linked to a regulatory role of pyrin and ZBP1, with the ability to induce PANoptosis through multi‐protein interactions of AIM2, pyrin, ZBP1, ASC, caspase‐1 and ‐8, RIPK‐3 and ‐1 and FADD through pyroptosis, apoptosis and necroptosis pathway interactions, following herpes simplex virus 1 (HSV‐1) and Francisella novicida (F. novicida) infection.125. This evidence concerns the gene ZBP1 and infection.