TLR7 and COVID-19: Moreover, other studies on SARS-CoV-2 have revealed the pathological role of TLR4 and TLR7/8 in excessive inflammatory response in COVID-19 patients as it leads to the formation of neutrophil extracellular traps (NETs) and the activation of inflammasomes, leading to acute lung injury (Khadke et al., 2020; Sohn et al., 2020; Veras et al., 2020).