Recently, a biomaterial COVID-19 vaccine based on mesoporous silica rods (MSRs) and loaded with MPLA, granulocyte-macrophage colony-stimulating factor (GM-CSF), and SARS-CoV-2 viral protein antigens was shown to slowly release their cargo and form subcutaneous scaffolds that recruited and activated antigen-presenting cells (APCs) at the local site to generate adaptive immune responses (Langellotto et al., 2021). This evidence concerns the gene CSF2 and COVID-19.