Relevant to the A391T variant allele found in humans, a mouse Zip8 A393T KI model exhibits increased vulnerability to chemically induced inflammatory bowel disease (IBD) as a consequence of defective Mn transport, (Sunuwar et al., 2020), which is consistent with previous GWAS studies conducted in patients with IBD, discussed more in depth below. This evidence concerns the gene SLC39A8 and inflammatory bowel disease.