In addition, BECN1-EEE NSCLC xenografts were poorly differentiated, exhibiting a phenotype similar to the more aggressive squamous lung cancer, and promotes de-differentiation of NSCLC xenograft from TTF-1 (homeodomain protein highly expressed in lung adenocarcinoma) positive adenocarcinomas to TTF-1 negative tumors with squamous differentiation features. This evidence concerns the gene TTF1 and adenocarcinoma.