FGF1 and asthma: For example, in asthma animal models established the same way and in platelet-derived growth factor (PDGF-BB)-treated primary mouse airway smooth muscle cells (ASMCs), overexpression of fibroblast growth factor 1 (FGF1) reduces the function of M2-sEVs and miR-370 was poorly expressed in both models but then recovered after M2Φ-Exos treatment, in turn, M2-sEVs can reduce lung injury and inflammation, inhibit ASMC proliferation and airway remodeling, and slow down asthma development by carrying miRNA-370, downregulating FGF1 expression and inhibiting the MAPK/STAT1 axis (Li et al., 2021d).