M2-sEVs strengthen radioresistance of LC cells, promote the malignant behavior of LC cells, and reduce survival of patients with LC after radiotherapy inducing the overexpression of AGAP2-AS1, downregulating miR-296, and upregulating notch homolog protein 2 (NOTCH2) (Zhang et al., 2021a). Here, NOTCH2 is linked to laryngotracheoesophageal cleft.