sEVs do not only act on recipient cells through miRNAs and lncRNAs but also play physiological functions by delivering proteins, such as polymorphic apolipoprotein E (ApoE), which plays a key role in cardiovascular and neurodegenerative diseases (MacRitchie et al., 2012) and inhibits tumor growth (Ha et al., 2009; Pencheva et al., 2012). Here, APOE is linked to neurodegenerative disease.