MiRNA-181a-5p delivered by M1-sEVs inhibit the expression of STK16 by targeting ETS1 to regulate cell viability and apoptosis in lung adenocarcinoma (LUAD), while STK16 silencing significantly reduces the mass of nodules in tumor models, thus promoting the apoptosis of LUAD cells (Wang et al., 2022a). Here, STK16 is linked to neoplasm.