DACT2 and skin basal cell carcinoma: The increased miRNA-503-3p load in M-sEVs promotes glycolysis and reduces mitochondrial oxidative phosphorylation (OXPHOS) in BCC cells, and activates the Wnt/β-catenin signaling pathway by reducing disheveled-associated binding antagonist of beta-catenin 2 (DACT2) expression, repressing oxygen consumption rate and adenosine-triphosphate (ATP) levels, promoting the malignant phenotype of BCC cells and promoting tumor progression (Huang et al., 2021a).