For example, tumor-promoting miRNA-27a-3p and miRNA-660-5p loaded in M2-sEVs lead to the overexpression of these in HCC cells, respectively, downregulating thioredoxin-interacting protein (TXNIP) and Krüppel-like factor 3 (KLF3) that can inhibit tumor development. This evidence concerns the gene KLF3 and neoplasm.