TWEAK is a multifunctional cytokine that mediates the anti-tumor effects of tumor-infiltrating Mφs by playing a role in the regulation of immune responses, thereby affecting the biological characteristics of multiple cancer cell types (Chicheportiche et al., 1997; Kaduka et al., 2005; Maecker et al., 2005). This evidence concerns the gene TNFSF12 and neoplasm.