In addition, M2-sEVs can contain high levels of miRNA-27a-3p and deliver it to hemangioma stem cells to inhibit their sensitivity to propranolol in infantile hemangioma (IH) by downregulating dickkopf-related protein 2 (DKK2) (Liu et al., 2021a). Here, DKK2 is linked to isolated hemihyperplasia.