KLF3 and hepatocellular carcinoma: These results suggest that M2-sEVs promote cancer stemness, drug resistance, migration, invasion, and tumorigenicity in HCC via miRNA-27a-3p/TXNIP and miRNA-660-5p/KLF3 pathways; however, they do not affect the proliferation of cancer cells (Li et al., 2021a; Tian et al., 2021).