Actin filament associated protein 1 antisense RNA1 (LncRNA AFAP1-AS1) delivered by M2-sEVs can downregulate miRNA-26a and upregulate activating transcription factor 2 (ATF2) to affect the migration and metastasis of esophageal cancer cells, as well as in vitro lung tumor metastasis in EC (Mi et al., 2020). Here, ATF2 is linked to esophageal cancer.