MiRNA-326, which can suppress the expression of tumor-related genes, is downregulated in HCC cells, but found in high levels in M1-sEVs, thereby reducing cell proliferation, colony formation, migration, and invasion, as well as NF-κB expression, promoting apoptosis of HCC cells, reducing the volume and weight of HCC tumors (Bai et al., 2020). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.