PRKN and Parkinson disease: Although new evidences are emerging about the regulatory function of mitochondria and cell metabolism during neurogenesis (Bueler, 2021), the involvement of Rho proteins in mitochondria homeostasis is still unclear: ROCK-I downregulates Parkin mediated mitophagy in PD (Moskal et al., 2020); on the other hand, activation of the RhoA/ROCK-I pathway results in the phosphorylation of Dynamin-related protein 1 (Drp1) which leads to mitochondria fission in cardiomyocytes under stress (Brand et al., 2018).