To notice, it has been reported that differentiation of stem cells into mature cells requires a switch from glycolysis to increased mitochondrial respiration (Chen et al., 2008; Maryanovich et al., 2015) and having in mind the role of defective mitochondria homeostasis in neurodegenerative diseases, our findings point at Rnd3 as a relevant player in maintaining CNS functions. Here, RND3 is linked to neurodegenerative disease.