According to the data from GEPIA 2 (http://gepia2.cancer-pku.cn/), expression of TMEM189 encoding plasmanylethanolamine desaturase that introduces the vinyl ether double-bond into plasmanylethanolamine (Gallego-García et al., 2019; Werner et al., 2020) is upregulated in most of the human cancers, although higher expression of TMEM189 reduces the protein level of Far1 (Cui et al., 2021). This evidence concerns the gene PEDS1 and cancer.