PCSK9 and ischemia: The results showed that the proportion of M2 macrophages was increased compared to the WT ischemia group (27.58 ± 0.97% vs. 43.34 ± 0.61%, P < 0.05) (Figure 4(a)), and the proportion of M1 macrophages was decreased in the PCSK9−/− ischemia group (45.32 ± 4.19% vs. 34.54 ± 2.95%, P < 0.05) (Figure 4(a)).