IL6 and ischemia: The results of the q-PCR and Western blot analyses showed that the expression of M1 macrophage markers (IL6, iNOS) was remarkably reduced in the PCSK9−/− ischemia group compared to the WT ischemia group (Figures 4(b)–4(d)), but the expression of M2 macrophage markers (TNF-β and CD206) was increased (Figures 4(b)–4(d)).