TGFB1 and posterior cortical atrophy: Also, HECTD1 overexpression significantly reversed the circGFRA1 overexpression-induced upregulation of VEGF, IL-10, and TGF-β1 in the supernatant of PCa cells (Figures 7(h)–7(j)) and rescued the circGFRA1 overexpression-regulated CIK cell-induced cytotoxic activity towards PCa cells (Figures 7(k) and 7(l)), suggesting that HECTD1 is essential for the functional role of circGFRA1 in PCa progression.