The schematic diagram of circGFRA1 is shown in Figure 1(c), and to confirm that circGFRA1 was indeed circular in PCa cells, cells are treated with the transcription inhibitor actinomycin D (ActD) showing that the half-life of circGFRA1 was significantly longer than GFRA1 mRNA (Figures 1(d) and 1(e)). Here, GFRA1 is linked to posterior cortical atrophy.