Also, HECTD1 overexpression significantly reversed the circGFRA1 overexpression-induced upregulation of VEGF, IL-10, and TGF-β1 in the supernatant of PCa cells (Figures 7(h)–7(j)) and rescued the circGFRA1 overexpression-regulated CIK cell-induced cytotoxic activity towards PCa cells (Figures 7(k) and 7(l)), suggesting that HECTD1 is essential for the functional role of circGFRA1 in PCa progression. Here, HECTD1 is linked to posterior cortical atrophy.