To explore whether the observed differences in vitamin C levels may support dysfunctions of physiological uptakes mechanisms, a quantitative assessment of SCL23A2, SLC2A1, and SLC2A3 transcripts was performed on PB-MNCs samples harvested at diagnosis from 22 AML cases and compared to those of 15 HDs. This evidence concerns the gene SLC2A3 and acute myeloid leukemia.