ERBB2 and breast cancer: Among all 65 HER2-positive BC patients with BM, the time from the diagnosis of BC to the development of BCBM was 36.3 months (95% CI: 30.0 to 42.1 months). The time from the diagnosis of first recurrence and metastasis stage to diagnosis of BCBM was 11.3 months (95% CI: 7.1 to 18.4 months). The time from the diagnosis of BCBM the time of follow-up was 24.1 months (95% CI: 13.9 to 37.5 months) (Figure 2).