As a downstream effector factor of programmed death-ligand 1 (PD-L1), tumor suppressor SIRT3 is inhibited by PD-L1 and participates in integrin β4 (ITGB4)/snail family transcriptional repressor 1 (SNAI1) signaling pathway to regulate glucose metabolism, which provides energy to promote metastasis in cervical cancer (62). Here, CD274 is linked to cervical cancer.