SIRT3 regulates the EMT-related markers such as E-Cadherin, N-Cadherin, and Vimentin to suppress EMT, especially in prostate cancer and small‐cell lung cancer, which may be related to Wnt/β-catenin/FOXO3α pathway and protein kinase B (AKT, also known as PKB)-dependent ferroptosis (79–81). This evidence concerns the gene AKT1 and prostate carcinoma.