In hepatocellular carcinoma cells, SIRT3 sensitizes hepatocellular carcinoma cells to chemotherapy drugs via regulating mitochondrial cyclooxygenase-2 (mito-COX-2)/Drp1 with phosphorylation at serine 616 (p-Drp1Ser616) and glutathione S-transferase pi 1 (GSTP1)/c-Jun N-terminal kinase (JNK) signaling pathway (97, 98). This evidence concerns the gene SIRT3 and hepatocellular carcinoma.