(15) have found some frequently mutated genes (mutation frequency >5%), such as TP53, ARID2, ZRSR2, TERT, AXIN1, APC, CTNNB1, BAP1, SF3B1, TSC2, and JAK1, in HCC compared with normal tissues by NGS. The gene discussed is CTNNB1; the disease is hepatocellular carcinoma.