Based on existing studies, it was observed that the mechanism of acupuncture in the treatment of infertility is mainly reflected in four ways, that is, by adjusting HPO axis balance, where acupuncture reduces the “high GnRH” and “high LH” status in PCO rats by increasing the expression of β-endorphins, which is beneficial to follicular development. This evidence concerns the gene GNRH1 and Infertility.