Recently, it has been showed that nonrandom clustering of LS-AO-BD disease-causing variants has at least two pathogenic mechanisms of generating these disease phenotypes, one of which relates to FLNB-actin-FLNA focal accumulation of the amount which was correlated with phenotype severity of LRS and the other possibly dysregulating the function of hinge 1 [20]. Here, FLNB is linked to Behcet disease.