(4), conducted in a small cohort of patients with T1D demonstrated that insulin-induced hypoglycemia that recovered by reaching hyperglycemia were associated with expression of oxidative stress (i.e. nitrotyrosine and 8-iso prostaglandin F2α) and inflammation (i.e. intracellular adhesion molecule-1a and interleukin-6) biomarkers (4). The gene discussed is INS; the disease is Hyperglycemia.