In the spline regression analyses, the risk of CHD decreased progressively with the serum levels of DHEA and DHEAS after adjusting for age, current smoking, current drinking, insurance type, BMI, duration of diabetes, SBP, LDL-C, FBG, HbA1c, and use of GLP-1 receptor agonists or SGLT-2 inhibitors (Figure 4). The gene discussed is SLC5A2; the disease is diabetes mellitus.