The percentage of men with CHD significantly decreased with increasing quartiles of serum DHEA (33.9% in quartile 1, 24.2% in quartile 2, 14.8% in quartile 3, and 10.2% in quartile 4; p < 0.001) and DHEAS (31.5% in quartile 1, 25.8% in quartile 2, 16.4% in quartile 3, and 9.4% in quartile 4; p < 0.001). This evidence concerns the gene SULT2A1 and coronary artery disorder.