Cancer associated gene (CAGE), G antigen 7 (GAGE7), RNA helicase autoantibodies GBU4-5 (GBU4-5), and melanoma antigen A1 (MAGE-A1) are all tumor-testis antigens, which are specifically expressed in a variety of malignant tumors and their levels are higher in LC patients [16, 17]. Here, MAGEA1 is linked to laryngotracheoesophageal cleft.