We further analyzed the ROC of serum seven-autoantibody in the diagnosis of different histological types of LC, and the results showed that the AUC of serum anti-CAGE, anti-GAGE7, anti-GBU4-5, anti-MAGE A1, anti-P53, anti-PGP9.5, and anti-SOX2 for the diagnosis of squamous cell carcinoma was 0.640 (95% CI: 0.576–0.705, P < 0.001) (Figure 3(a)). Here, SOX2 is linked to squamous cell carcinoma.