Consistent with the presumed synergistic effect on mitotic exit, APC/C-inhibition alone or combined with a taxane can lead to strong mitotic cell death in certain tumor cells, but in others with high expression of the anti-apoptotic regulator Mcl-1, cell death is induced in interphase (Zeng et al., 2010; Raab et al., 2020; Greil et al., 2021). Here, APC is linked to neoplasm.