In addition, many E3 ligases have been reported to play vital roles in glioma carcinogenesis via the regulating PI3K/Akt pathway, such as SCFβ−TrCP (Warfel et al., 2011), TRAF6 (Feng et al., 2014), and TRIM21 (Lee et al., 2017). Here, AKT1 is linked to glioma.