The PI3K/Akt signaling could be modulated by the SCFβ−TrCP complex and SCFSkp2 complex and regulate the proliferation of primary GBM cell lines, glioma stem cells (GSCs), and established GBM cell line models (Winston et al., 1999; Li et al., 2009; Yang et al., 2009; Chan et al., 2012; Feng et al., 2014). The gene discussed is AKT1; the disease is glioma.