CD274 and amyotrophic lateral sclerosis: KEGG pathway analysis results demonstrated that the substrates were mostly correlated with neurodegeneration (pathways of neurodegeneration, Parkinson’s disease, and amyotrophic lateral sclerosis), cell death (mitophagy, apoptosis, and autophagy), and immune response (NOD-like receptor signaling pathway, PD-L1 expression, and PD-1 checkpoint pathway in cancer) (Figure 11D).