Studies have shown that C′-truncation of MYBPC3 causes cMyBP-C null and DCM in mice at the age of 3 months (McConnell et al., 1999), as well as significant epigenetic changes (Tabish et al., 2019), indicating the importance of normal cMyBP-C for regular cardiac function (Lynch et al., 2015). The gene discussed is MYBPC3; the disease is familial dilated cardiomyopathy.