TMED5 and cancer: Moreover, the TMEM33 expression level was remarkably positively correlated with similar genes of RNF4, OCIAD1, TMED5, DHX15, MED28 and LETM1 (Figure 5C), which have been reported to be implicated in tumorigenesis of various cancers (Sengupta et al., 2008; Thomas et al., 2016; Hsieh et al., 2019; Xie et al., 2019; Ji and Hu, 2020; Zou et al., 2021).