Recently, we found that sestrin 2 improved the outcome of sepsis by decreasing the NLRP3/caspase-1-dependent pyroptosis, and it was closely related to the protein kinase RNA (PER)-like ER kinase (PERK)-activating transcription factor (ATF)4-C/EBP homologous protein (CHOP) pathway (95). This evidence concerns the gene DDIT3 and Sepsis.