In the previous studies, we found that HMGB1 in the CNS could induce immune depression of DCs by triggering the hyperactivation of the CAP in CLP-induced septic mice, and the inhibition of cerebral HMGB1 significantly protected the brain against sepsis-induced injury and improved the immune function of splenic T cells (156–158). Here, HMGB1 is linked to Sepsis.