Then, StarBase database was employed to confirm the expression levels of Top10 hub mRNA and found that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN were downregulated in endometrial carcinoma tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 were upregulated in endometrial carcinoma tissues. This evidence concerns the gene LEFTY1 and endometrial carcinoma.