The regulatory networks of CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 were preliminarily identified, which can present novel perspectives toward the pathogenesis of endometrial cancer. This evidence concerns the gene LHX3 and endometrial cancer.