HIF1A and cancer: Transcriptionally, LDHA is regulated by forkhead box protein M1 (FOXM1), hypoxia-inducible factors (HIF-1α and HIF-2α), Jumonji C Domain 2A (JMJD2A), and peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1-beta (PGC1β) in cancer cells 12.