ADAM8 and Sepsis: Similar to our results in the experimental model, LAMP3+ DCs in COVID-19 patients were identified as a cluster of human sepsis associated mregDCs that highly expressed maturation (CD40, CD80, CD86, CD83)- and migratory (CCR7, MYO1G, ADAM8, FSCN1, MARCKS, MARCKSL1)-related marker genes as well as immunoregulatory molecules (CD274, PDCD1LG2, CD200, ALDH1A2, SOCS2), along with low expression of TLR signaling pathway genes (Figure 9G; Table S13).