Intriguingly, in contrast to the previous study where tumor-associated mregDCs lacked expression of cDC1 and cDC2-related signature genes, we noted that sepsis-induced mregDCs expressed low or intermediate level of cDC2-specific markers, including Sirpa, Runx3, and Zbtb46. Meanwhile, the UMAP clustering analysis closely associated sepsis mregDCs with the canonical cDC2 subset, suggesting that sepsis-induced mregDCs might originate from cDC2s. This evidence concerns the gene MPPE1 and Sepsis.