Furthermore, increased infiltration of IFN-γ+ CD8+ T cells was detected in FGFRi-treated 4T1 tumors and further improved in FGFRi plus ICT combination group (Figure 6F), which suggests that boosted cytotoxic activities of CD8+ T cells also contribute to FGFRi blockade-mediated anti-tumor immunity. This evidence concerns the gene CD8A and neoplasm.