Remarkably, complete tumor remission was observed in 60% of the combination treatment group but none of the other groups (Figure 6D), along with significantly increased CD4+ and CD8+ T cell infiltration, and decreased infiltration of myeloid-derived suppressor cells (MDSC), macrophages (Mφ) and regulatory T cells (Treg) (Figure 6E, Figure S6C-F). The gene discussed is CD8A; the disease is neoplasm.