Then, a close inspection of the dataset revealed the presence of (i) the hyalectan versican, able to bind ECM components, chemokines, growth factors, CD44 (present in cATMSC-EV), and capable to modulate a wide range of cellular responses, such as cell inflammatory activation; (ii) the antioxidant agent thioredoxin, a potent cardioprotective against ischemia-reperfusion injury 14,15; and (iii) the small leucine-rich proteoglycans class I biglycan, decorin and class II lumican, crucial to reduce cardiac fibrosis and dysfunction 16. This evidence concerns the gene VCAN and ischemia reperfusion injury.