MAPT and Atrophy: Neuropathological reports of patients with MND-parkinsonism are conflicting, describing various combinations of Lewy bodies, ubiquitinated cytoplasmic inclusions, tau pathology and atrophy in disease-associated brain regions, as well as a loss of dopaminergic neurons in the substantia nigra (Uitti et al., 1995; Mackenzie and Feldman, 2004; Liang et al., 2005).