Conversely, MND-CBS cases may be associated with predominant TDP-43 pathology as suggested by recent reports (Murakami et al., 2022; Seibert et al., 2022), while PLS-PSP cases could be explained by tau, TDP-43, or a combination of both pathologies (Liu et al., 2000). This evidence concerns the gene TARDBP and mild neurocognitive disorder.