In a non-ICU setting (general medicine or surgery) the recommended total daily insulin dose for most people should start between 0.15-0.3 units/kg body weight, with lower doses of 0.1-0.15 units/kg recommended for older patients with renal failure (eGFR < 60 mL/min/1.73 m2), history of hypoglycemia, or poor oral intake [252]. The gene discussed is INS; the disease is Hypoglycemia.