SAE1 and mantle cell lymphoma: The high correlation of expression of cell cycle, chromosome segregation and centromere related genes with SAE1 and SAE2 upregulation in MCL patient samples (Fig. 3A) along with the significant degree of mitotic dysregulation seen in many MCL cell lines and primary MCL samples after inhibition of SAE2 (Fig. 3B, C) strongly suggests that upregulation of the sumoylation pathway is serving a crucial role in maintaining mitotic fidelity in MCL cells in the face of their high degree of proliferation and severe cell cycle checkpoint dysfunction.