CDC25C and mantle cell lymphoma: We found that induction of total and phosphorylated levels of the G2M transition proteins CDC25C (pS216), CDK1 (pT161), and H3 (pS10) remained intact despite TAK-981 treatment in both Jeko and Z-138 cells (Fig. 4D) with an overall higher level of pH3S10 in TAK-981 treated MCL cells likely due to a delay of cells through mitotic progression.