A similar breast cancer-promoting rule of RNF8 was also demonstrated by Lee et al., which showed that RNF8 facilitates cancer chemoresistance and progression through activation of Twist, a transcriptional control factor of the epithelial–mesenchymal transition, by RNF8-mediated K63-linked polyubiquitin [4, 15]. Here, TWIST1 is linked to breast carcinoma.