RNF8 and keratosis: In addition, the correlation between RNF8 and many of the identified pathways such as oncogenic MAPK pathways, epigenetic regulation, TGF-beta receptor, sumoylation, integumentary system disease, keratosis, skin disease (Additional file 3: Fig. S3A and B), and most of the identified target proteins, has not been reported, which underscores deeper exploration and more mechanistic insights toward RNF8.