We also revealed the unrecognized relationship between RNF8 and neurodegenerative diseases or tumor-infiltrating immune cells, and validated the direct binding between RNF8 and YBX1, and showed that RNF8 catalyzed the ubiquitination of YBX1, showing that RNF8 might be a crucial regulator of YBX1. Here, RNF8 is linked to neoplasm.