RNF8 and lung adenocarcinoma: In addition, significant downregulation of RNF8 was observed in kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), prostate adenocarcinoma (PRAD) and thyroid carcinoma (THCA) (Fig. 1A, Additional file 1: Fig. S1A and Additional file 1: Fig. S1B).